ncRNA name | rno-miR-23b-3p |
ncRNA Category | miRNA |
Disease name | diabetic retinopathy (DR) |
Species | Rattus norvegicus |
Tissues/Cell_line | retinas |
Methods | microarray, qRT-PCR, luciferase reporter assay, Chromatin immunoprecipitation (CHIP), in situ hybridisation |
Expression pattern | up-regulated |
Functional description | High glucose increased miR-23b-3p expression, even after the return to normal glucose. Luciferase assays identified SIRT1 as a target mRNA of miR-23b-3p. Reduced miR-23b-3p expression inhibited Ac-NF-κB expression by rescuing SIRT1 expression and also relieved the effect of metabolic memory induced by high glucose in HRECs. |
PubMed ID | 26687158 |
Year | 2016 |
Title | miR-23b-3p induces the cellular metabolic memory of high glucose in diabetic retinopathy through a SIRT1-dependent signalling pathway. |
Drug-related ncRNA | NO |
Copyright © Institution of Biomedical Big Data, Wenzhou Medical University All rights reserved.